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Perit Dial Int 28(6): 668-672
2008
© 2008 International Society for Peritoneal Dialysis
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SHORT REPORTS

Bone Mineral Density, Vascular Calcifications, and Arterial Stiffness in Peritoneal Dialysis Patients

Teresa Adragao1,*, Patrícia Branco2, Rita Birne1, José Dias Curto3, Edgar de Almeida2, Mateus Martins Prata2 and Maria Joao Pais1

Nephrology Department1 Santa Cruz Hospital, Carnaxide Nephrology Department2 Santa Maria Hospital ISCTE Business School3 Lisbon, Portugal

* e-mail: tadragao{at}netcabo.pt

The objective of this study was to evaluate the correlation of bone mineral density (BMD), evaluated by DXA, with vascular calcifications, arterial stiffness, and vascular disease in patients on peritoneal dialysis. Vascular calcifications were evaluated by vascular calcification score on plain x ray, and arterial stiffness was measured by pulse wave velocity using the Complior device (Artech Medical, Pantin, France). Adjusting for multiple factors, lower BMD at the femoral neck, but not at the lumbar spine, was associated with higher pulse wave velocity (p = 0.037), higher vascular calcification score (p = 0.013), and peripheral artery disease (p = 0.006). These data reinforce the hypothesis of the existence of a link between bone disease and cardiovascular disease in dialysis patients.

KEY WORDS: Bone mineral density; vascular calcifications; arterial stiffness.






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