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Perit Dial Int 28(6): 577-584
2008
© 2008 International Society for Peritoneal Dialysis
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IN-DEPTH REVIEW

CLAUDIN TIGHT JUNCTION PROTEINS: NOVEL ASPECTS IN PARACELLULAR TRANSPORT

Constanze Will1,2, Michael Fromm3 and Dominik Müller1,2

Department of Pediatric Nephrology,1 Center for Cardiovascular Research,2 Institute of Clinical Physiology,3 Charité, Berlin, Germany

Correspondence to: D. Müller, Department of Pediatric Nephrology, Charité, Augustenburger Platz 1, 13353 Berlin, Germany. dominik.mueller{at}charite.de

Claudins are essential components of the intercellular tight junction and major determinants of paracellular solute fluxes across epithelia and endothelia. Many members of this family display a distinct charge or size specificity, whereas others render the epithelium impermeable to transport. Due to intercellular localization, claudin-mediated transport processes are passive and driven by an electrochemical gradient. In epithelial tissues, claudins exhibit a temporal–spatial expression pattern corresponding with regional and local solute transport profiles. Whereas paracellular transport mechanisms in organs such as intestine and kidney have been extensively investigated, little is known about the molecular mechanisms determining solute transport in the peritoneum, and thus the determinants of peritoneal dialysis. Given the ubiquitous expression of claudins in endothelia and epithelia, it is predictable that claudins also contribute to pore formation and determination in the peritoneum, and that they are involved in solute flux. Therefore, we review the basic characteristics of claudin family members and their function as exemplified in renal tubular transport and give an outlook to what extent claudin family members might be of importance for solute reabsorption across the peritoneal membrane.

KEY WORDS: Tight junction; claudin; kidney; peritoneum.

Received 3 June 2008; accepted 22 September 2008.






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