PDI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Perit Dial Int 28(4): 352-360
2008
© 2008 International Society for Peritoneal Dialysis
This Article
Right arrow Full Text (PDF)
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moon, S. J.
Right arrow Articles by Han, D.-S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Moon, S. J.
Right arrow Articles by Han, D.-S.

ORIGINAL ARTICLES

RISK FACTORS FOR ADVERSE OUTCOMES AFTER PERITONITIS-RELATED TECHNIQUE FAILURE

Sung Jin Moona , Seung Hyeok Hana, Dong Ki Kim, Jung Eun Lee, Beom Seok Kim, Shin-Wook Kang, Kyu Hun Choi, Ho Yung Lee and Dae-Suk Han

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea

Footnotes

a S.J. Moon and S.H. Han contributed equally to this paper.

Correspondence to: D.S. Han, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong Seodaemun-gu, Seoul, 120-752 Korea. dshan{at}yumc.yonsei.ac.kr

{diamondsuit} Background: Peritonitis is the leading cause of technique failure in peritoneal dialysis (PD) patients. Some patients experience recurrent ascites, encapsulating peritoneal sclerosis (EPS), and even death after catheter removal. Little is known, however, about the risk factors for such complications.

{diamondsuit} Methods: The study subjects were 117 patients that had their PD catheter removed due to peritonitis between January 2000 and June 2006. Biochemical and clinical data were reviewed retrospectively. Serum C-reactive protein (CRP) and blood and effluent white blood cell counts (WBC) were measured at baseline and at 72 hours of peritonitis. Based on adverse outcomes, patients were classified into 4 groups: non-complication (NC; n = 73), recurrent ascites (A; n = 26), EPS (E; n = 10), and death directly related to peritonitis (D; n = 8).

{diamondsuit} Results: Age at PD catheter removal was significantly higher in D group compared to NC group (62.0 ± 10.6 vs 51.2 ± 11.5 years, p < 0.05). In addition, mean PD duration was significantly longer in E group compared to NC and A groups (130.5 ± 48.1 vs 58.8 ± 42.4 vs 74.8 ± 47.4 months, p < 0.01). Compared to baseline, effluent WBC was significantly decreased in NC group after 72 hours of peritonitis. In addition, serum CRP level was significantly decreased in NC and A groups, whereas it was significantly increased in D group. Multivariate analyses adjusted for age, PD duration, blood and effluent WBC, serum CRP, and micro-organisms revealed that serum CRP level at 72 hours predicted significantly the development of EPS [odds ratio (OR) 1.15, p < 0.05] and peritonitis-related death (OR 1.18, p < 0.01). In addition, PD duration (per 1 month increase: OR 1.03, p < 0.05) and age at PD catheter removal (per 1 year increase: OR 1.11, p < 0.05) were identified as significant determinants of EPS and peritonitis-related death respectively. Only effluent WBC at 72 hours was significantly associated with the development of ascites (OR 1.27, p < 0.05).

{diamondsuit} Conclusion: Older patients with long PD duration and those with persistently elevated serum CRP levels were likely to develop complications after peritonitis-related technique failure. Our study suggests that serial measurement of CRP may be helpful in predicting the development of complications after PD catheter removal.

KEY WORDS: Peritonitis; C-reactive protein; complications.

Received 1 October 2007; accepted 21 February 2008.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Multimed Inc. logo
Copyright © 2008 by Multimed Inc.